22 results
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
Decreased ENaC channel function ... Aldosterone Receptor Function ... #Hyperkalemia #Pathophysiology ... #Pharmacology #
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... : Inhibits the function ... heparin (LMWH): Functions ... #Pharmacology #Pathophysiology
Causes of Urinary Tract Obstruction - Differential Diagnosis Algorithm
Upper Tract - Bladder NOT distended on ultrasound,
Fibrosis • Cancer ... Ureteropelvic junction ... • Prostate cancer ... Algorithm #Causes #Urology
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Nephron and their Functions ... Nephron #Segments #Function ... #Pathophysiology ... Tubules #Table #Pharmacology
NSAID vs ACEI/ARB effects on the Kidneys

Remember that NSAIDs and ACEI/ARB therapy have opposing effects on
normal kidney function ... it's more of a concern ... Nephrology #Renal #Pathophysiology
Priapism: Pathogenesis

 - Post-cavernosal venous occlusion -> Post-cavernosal venous drainage is mechanically obstructed e.g. sickle cell
Inadequate venous function ... #Priapism #Pathophysiology ... #Urology #Diagnosis
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
decline in mental function ... #emergencies #oncology ... differential #diagnosis #cancer
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... #Chemotherapy #Oncology ... Interactions #Table #Pharmacology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
has very minimal chance ... check the kidney function ... Renal #Dosing #Pharmacology
Checkpoint inhibitors and indications
Anti CTLA-4 antibody:
 • Ipilimumab: Malignant melanoma, Renal cell cancer
Anti-PD-1 antibody:
 • Nivolumab:
, Renal cell cancer ... , Gastric cancer ... , Solid cancers ... #indications #oncology ... #pharmacology