1032 results
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... Maintenance: 10 g ... intervals in 5-g ... QoD to 15 g QD ... of aspiration #Potassium
Drugs that Impair Renal Potassium Excretion 

Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine
Decreased Aldosterone Synthesis: Heparin,
that Impair Renal Potassium ... #Hyperkalemia #Pathophysiology ... Pharmacology #Impaired #Potassium
Veltassa (Patiromer) 
MECHANISM: Potassium Binder 
INDICATION: Treatment of Hyperkalemia 
FORMULATION: Powder for oral suspension 
DOSING: 8.4
) MECHANISM: Potassium ... DOSING: 8.4 g ... Increase by 8.4 g ... week, up to 25.2 g ... patiromer) is a potassium
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
treated with IV potassium ... ratio < 15 mEq/g ... ratio > 15 mEq/g ... #differential #potassium
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
HCTZ) 5) Potassium-sparing ... spironolactone) #Pathophysiology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
pernicious anemia) • G-CSF ... nephrology #low #potassium
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
the basis of the potassium-to-creatinine ... K+ <13 mEq K+/g ... K+ >13 mEq K+/g ... hypokalemia #urine #potassium
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Pharmacology and Pathophysiology ... pump and prevents potassium ... the cell, serum potassium ... the same site as potassium ... #Pharmacology #Pathophysiology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Algorithm #causes #potassium ... #low #pathophysiology
Checklist Approach to Hypokalemia

Consider risk factors for arrhythmia:
 - EKG changes (especially QT prolongation)
 - Digoxin
safely, whereas potassium ... Consider target potassium ... Enteral potassium ... function & estimated potassiurn ... Intravenous potassium