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diagnosis hematology oncology hemophagocytic lymphohistiocytosis acromegaly apml causes chronic classification differentiation endocrinology erythematosus hemeonc hodgkins icl idiopathic leukemia lupus lymphocytic
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... Autoimmune diseases: SLE ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... non-Hodgkin lymphoma SLL ... weeks without infection ... surface molecules: CD5 ... microglobulin Treatment
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
T-cell count of ... Autoimmune (Sjogren, SLE ... myelodysplasia) • Infections ... #diagnosis #hematology ... #Differential #
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Triggers: ▪ Infections ... of NK cells and CD8 ... underlying trigger: Infections ... #Hematology #HemeOnc
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
erythematosus (SCLE ... permanent alopecia Differential ... Non-autoimmune rheumatologic ... fibromyalgia) • Infections ... La, anti-Jo-1, SCL
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... • Induce blast cell ... initiation • Differential ... Diagnosis: Infection ... APML #diagnosis #management
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
Summary - GrepMed ... pancreatic islet cell ... Differential Diagnosis ... adenoma, ↓(TFT, LH ... Endocrinology #Treatment
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... History of EBV infection ... Immunohistochemical studies (to differentiate ... Hodgkin Lymphoma Treatment ... #oncology #management
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
Diagnosis and Management ... Summary WHAT ... hypothyroidism, infection ... normal and can help differentiate ... #Rheumatology
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