2034 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... cold agglutin disease ... G6PD deficiency) ... e.g. sickle cell disease ... Hypersplenism, Wilson's disease
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell disease ... , Hemoglobin H disease ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... Immune mediated hemolysis ... malignancy, autoimmune disease ... Microangiopathic hemolytic
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC: Pyridoxine deficiency ... Thalassemia, Iron deficiency ... Microangiopathic Hemolytic ... spherocytosis, Autoimmune hemolytic ... Cold autoimmune hemolytic
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
inflammation) • Iron deficiency ... -100): • Non-hemolytic ... anemia, CKD • Hemolytic ... , B12 deficiency ... Non-megaloblastic: Liver disease
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Microcytic - Iron-deficiency ... anemia, Liver diseases ... spherocytosis, Hemolytic ... , Liver diseases ... Schistocytes - Hemolytic
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework
LOW RETIC INDEX - ↓ PRODUCTION
 • Vitamin
, Folate deficiency ... Peptic ulcer disease ... anemia, Autoimmune hemolytic ... anemia, Hemolysis ... related to Wilson's disease
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Asplenism, Severe hemolytic ... Heinz Bodies: G6PD deficiency ... Sideroblastic anemia, Hemolytic ... : Hemoglobin H disease
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Microangiopathic hemolytic ... Microspherocytes: Autoimmune hemolytic ... cells: Sickle cell disease ... Bite cells: G6PD deficiency
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
, deficiency of ... anemia, folic acid deficiency ... - Iron deficiency ... • Legionnaires disease ... or particular disease