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Clinical Manifestations of Human Herpes Viruses (HHV)

Herpes simplex virus 1	HSV-1	Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... herpes virus 6 HHV ... herpes virus 7 HHV ... herpesvirus 8 HHV ... Herpes #Viruses #HHV
Kaposi Sarcoma Herpes Virus (KSHV)

By Dr. Sara Dong @swinndong via #IDFellowCase
#ID  #Infectious Diseases  #Infections
#Differential
#IDFellowCase #ID ... Diagnosis #KSHV #HHV
IDSA - Prophylaxis to Prevent First Episode of Opportunistic Disease in HIV-AIDS
 • Pneumocystis pneumonia (PCP)
IDSA - Prophylaxis ... Papillomavirus (HPV ... Hepatitis A virus (HAV ... Hepatitis B virus (HBV ... #OIs #HIVAIDS #IDSA
Infection-Related Cancers
Viruses:
 • HPV - Cervical, anogenital, head and neck, skin cancer
 • HTLV-1 - Adult
Cancers Viruses: • HPV ... T-cell Leukemia • HIV ... cell carcinoma • HBV ... / HCV - Hepatocellular ... carcinoma • HHV
IDSA - Prophylaxis to Prevent First Episode of Opportunistic Disease in HIV-AIDS
 • Pneumocystis pneumonia (PCP)
IDSA - Prophylaxis ... Papillomavirus (HPV ... Hepatitis A virus (HAV ... Hepatitis B virus (HBV ... #OIs #HIVAIDS #IDSA
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation
Kaposi sarcoma (KS):
 • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... • Association HIV ... Light chain: - HHV8 ... • Association HIV ... de Fremont #HHV8
Immunizations for People Living with HIV (PLWH)
 • HPV
 • Hepatitis
 • Influenza
 • Meningococcal
 •
People Living with HIV ... (PLWH) • HPV ... MMR • Others ID ... Immunizations #PLWH #HIV
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
• unicentric, HHV8 ... Plasmablastic subtype is HHV8 ... myeloma, POEMS) HHV8
Herpes Virus Antiviral Coverage Pyramid

*This chart only covers the herpes virus family, and does not include
involvement of an ID ... Coverage #Pyramid #HSV ... #VZV #HHV6 #HHV7
IDSA Recommendations for Preventing and Treating HHV-8 Diseases—Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL), Multicentric Castleman’s
IDSA Recommendations ... Preventing and Treating HHV ... activity against HHV ... adjunctive therapy #HHV8 ... KaposiSarcoma #Castlemans #IDSA