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KSHV Inflammatory Cytokine Syndrome (KICS) By Dr. Sara Dong @swinndong via #IDFellowCase #ID #Infectious Diseases
KSHV Inflammatory ... ID #Infectious Diseases ... Diagnosis #KSHV #HHV
KSHV Inflammatory Cytokine Syndrome (KICS) Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory ... KSHV-multicentric Castleman disease ... Infectious Diseases ... #KICS #KSHV #Inflammatory ... diagnosis #management #hhv8
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
production of pro-inflammatory ... Virus (EBV, CMV, HHV8 ... • Autoimmune diseases ... Adult-onset Still disease
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
Castleman's Disease ... • unicentric, HHV8 ... with Castleman's disease ... Plasmablastic subtype is HHV8 ... myeloma, POEMS) HHV8
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Reconstitution Inflammatory ... worsening of that disease ... with exaggerated inflammatory ... pericarditis, peritoneal disease ... Kaposi sarcoma, HHV8
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation Kaposi sarcoma (KS): • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... diseases: From ... Light chain: - HHV8 ... de Fremont #HHV8 ... #diseases #comparison
Eosinophils (Eos) and hypereosinophilia (HE) Caused by eosinophilopoietic cytokines Common causes: - Drug reaction - Helminth infection -
HTLVI) - Chronic inflammatory ... diseases (EGPA, ... , IgG4-related disease ... , inflammatory bowel ... diseases,
Clinical Manifestations of Human Herpes Viruses (HHV) Herpes simplex virus 1 HSV-1 Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... Mononucleosis-like disease ... herpes virus 6 HHV ... herpes virus 7 HHV ... herpesvirus 8 HHV
Seronegative Inflammatory Arthritis - Differential Diagnosis • Seronegative Rheumatoid Arthritis • Infectious Arthritis: Viral, Bacterial,
Seronegative Inflammatory ... Systemic Rheumatic Disease ... Sclerosis, Sjogren's Disease ... Sarcoidosis, Still's Disease ... , Inflammatory Myopathy
Inflammatory bowel disease: Crohn disease compared to Ulcerative colitis #Crohns #Disease #Ulcerative #Colitis #Comparison #Table #Manifestations
Inflammatory bowel ... disease: Crohn ... disease compared ... colitis #Crohns #Disease
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