12 results
Kaposi Sarcoma Herpes Virus (KSHV)

By Dr. Sara Dong @swinndong via #IDFellowCase
#ID  #Infectious Diseases  #Infections
#Differential
Herpes Virus (KSHV ... Ddx #Diagnosis #KSHV ... #HHV #lymphoproliferative ... #KICS
KSHV Inflammatory Cytokine Syndrome (KICS)

By Dr. Sara Dong @swinndong  via #IDFellowCase
#ID  #Infectious Diseases
KSHV Inflammatory ... Cytokine Syndrome (KICS ... Ddx #Diagnosis #KSHV ... #HHV #KICS #Kaposi
Clinical Manifestations of Human Herpes Viruses (HHV)

Herpes simplex virus 1	HSV-1	Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Herpes Viruses (HHV ... herpes virus 6 HHV ... herpes virus 7 HHV ... herpesvirus 8 HHV ... Herpes #Viruses #HHV
Infection-Related Cancers
Viruses:
 • HPV - Cervical, anogenital, head and neck, skin cancer
 • HTLV-1 - Adult
Cancers Viruses: • HPV ... T-cell Leukemia • HIV ... cell carcinoma • HBV ... / HCV - Hepatocellular ... carcinoma • HHV
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation
Kaposi sarcoma (KS):
 • Target organs: Ubiquitous (cutaneous and mucosal
HHV8/KSHV-reIated ... • Association HIV ... Light chain: - HHV8 ... • Association HIV ... de Fremont #HHV8
Transplant Infections Timeline
Pre-transplant:
 • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut)
 • Viruses: HSV (reactivation)
Engraftment:
gut) • Viruses: HSV ... airways) • Viruses: HSV ... reactivation), RSV ... reactivation), HHV ... 6, Adenovirus, RSV
KSHV Inflammatory Cytokine Syndrome (KICS)
Working Case Definition for KICS: Requires at least 2 clinical manifestations (from
KSHV Inflammatory ... Cytokine Syndrome (KICS ... Definition for KICS ... ID_fellows #KICS ... diagnosis #management #hhv8
IDSA Recommendations for Preventing and Treating HHV-8 Diseases—Kaposi Sarcoma (KS), Primary Effusion Lymphoma (PEL), Multicentric Castleman’s
Preventing and Treating HHV ... Disease (MCD) in HIV-AIDS ... and uncontrolled HIV ... activity against HHV ... adjunctive therapy #HHV8
Herpes Virus Antiviral Coverage Pyramid

*This chart only covers the herpes virus family, and does not include
Coverage #Pyramid #HSV ... #VZV #HHV6 #HHV7
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
of treatment of HIV ... a decrease in HIV ... pancreatitis • HBV ... , HCV - Hepatic ... Kaposi sarcoma, HHV8