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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilia ... and Hypereosinophilic ... • Secondary Hypereosinophilic ... MatthewHoMD #Hypereosinophilia ... #Hypereosinophilic
Hypereosinophilia (HE) Summary

 • Definition
 • When to Suspect?
 • A Partial Classification of Hypereosinophilia
 •
Hypereosinophilia ... Classification of Hypereosinophilia ... @ZhuoerXie #Hypereosinophilia
Hypereosinophilia Different Diagnosis and Workup
Secondary causes are broad so start with a med review, the most
Hypereosinophilia ... BostonChiefs #Hypereosinophilia
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
Eosinophils (Eos) and hypereosinophilia ... #Eosinophils #hypereosinophilia
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... Alert_Oriented3 #Hypereosinophilia
When to look for clonal/neoplastic hypereosinophilia (HEo)?
 - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
clonal/neoplastic hypereosinophilia ... #Neoplastic #hypereosinophilia
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
blood eosinophilia/hypereosinophilia ... 1,500 cells/µL • Hypereosinophilia
Causes of Leukocytosis and Leukopenia - Differential Diagnosis
 • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Eosinophilia (AEC > 500, hypereosinophilia
Differential Diagnosis of Pulmonary Eosinophilia
Infection:
 • Helminthic: Loffler syndrome (Ascaris, hookworm, Strongyloides), Tropical pulmonary eosinophilia (lymphatic
eosinophilia, Hypereosinophilic
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Leukemia - Primary Hypereosinophilic