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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
and Treatment Algorithm ... Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis ... #management #algorithm
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Testing Algorithm ... /hypereosinophilia ... 1,500 cells/µL • Hypereosinophilia ... #Disorders #Algorithm ... Differential #diagnosis #hematology
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Diagnosis Algorithm ... : • Primary hypereosinophilic ... AI: EGPA, IgG-4 disease ... , Behcet disease ... Differential #Diagnosis #Algorithm
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
No Asthma and Eosinophilia ... Both asthma and eosinophilia ... and/or 10%) - Eosinophilic ... differential #diagnosis #algorithm ... #rheumatology
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Leukemia - Primary Hypereosinophilic ... coyefish379 #Eosinophilia ... Diagnosis #Causes #hematology
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
Eosinophils (Eos ... ) and hypereosinophilia ... , IgG4-related disease ... TerrierBen #Eosinophils ... #hypereosinophilia
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... attributable to eosinophilia ... with blood eosinophilia ... Alert_Oriented3 #Hypereosinophilia ... #diagnosis #hematology
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Approach to Eosinophilic ... Lung Diseases ... • Acute Eosinophilic ... , CV, renal • Hypereosinophilic ... #Lung #Diseases
2021 ACR/VF Guidelines for Management of Eosinophilic Granulomatosis with Polyangiitis (EGPA)

#EGPA #Eosinophilic #Granulomatosis #Polyangiitis #ACR2021 #Management
Management of Eosinophilic ... (EGPA) #EGPA #Eosinophilic ... ACR2021 #Management #rheumatology ... #algorithm #vasculitis
Categories of disease to consider for eosinophilic meningitis:
-Multicellular parasites (worms and flukes)
-Fungal: Cocci
-Atypical bacterial/mycobacterial: TB, syphilis,
Categories of disease ... to consider for eosinophilic ... Hypereosinophilic ... -Infiltrative disease ... #Eosinophilia #