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Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilia ... and Hypereosinophilic ... Syndrome #HES #Hematology ... #eosinophilia # ... eosinophils #diagnosis
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... DRESS - AIN - Eosinophilic ... Asthma Tugs (vasculitis ... Leukemia - Primary Hypereosinophilic ... Diagnosis #Causes #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... /hypereosinophilia ... 1,500 cells/µL • Hypereosinophilia ... Differential #diagnosis #hematology ... #eosinophilia
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated Vasculitis ... No Asthma and Eosinophilia ... and/or 10%) - Eosinophilic ... StanfordChiefs #ANCA #Vasculitis ... diagnosis #algorithm #rheumatology
Hypereosinophilia Syndrome (HES) - Diagnosis and Management
Definition: An absolute eosinophil count (AEC) greater than 1500 and
Hypereosinophilia ... attributable to eosinophilia ... with blood eosinophilia ... Alert_Oriented3 #Hypereosinophilia ... #diagnosis #hematology
Small Vessel Vasculitides
 • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
Small Vessel Vasculitides ... Interstitial lung disease ... • Eosinophilic ... polyangiitis - Asthma. eosinophilia ... Cryoglobulinemic vasculitis
Eosinophilia - Differential Diagnosis Algorithm
Idiopathic Eosinophilia
Primary Eosinophilia:
 • Primary hypereosinophilic syndrome
 • Eosinophilic Leukemia
 • MPN/MDS
Primary Eosinophilia ... : • Primary hypereosinophilic ... AI: EGPA, IgG-4 disease ... , Behcet disease ... Chronic inflammatory disease
Eosinophils (Eos) and hypereosinophilia (HE)
Caused by eosinophilopoietic cytokines
Common causes:
 - Drug reaction
 - Helminth infection
 -
Eosinophils (Eos ... ) and hypereosinophilia ... , IgG4-related disease ... TerrierBen #Eosinophils ... #hypereosinophilia
Hypereosinophilia (HE) Summary

 • Definition
 • When to Suspect?
 • A Partial Classification of Hypereosinophilia
 •
Hypereosinophilia ... Classification of Hypereosinophilia ... @ZhuoerXie #Hypereosinophilia ... #HE #hematology
ANCA Vasculitis - GPA, MPA, Eosinophilic GPA

doi:10.1038/s41572-020-0204-y

#ANCA #Vasculitis #GPA #MPA #Eosinophilic #rheumatology #diagnosis #comparison #table
ANCA Vasculitis ... - GPA, MPA, Eosinophilic ... 0204-y #ANCA #Vasculitis ... #GPA #MPA #Eosinophilic ... #rheumatology #