12 results
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Differential diagnosis of myopathy ... Fibromyalgia #Hypothyroid ... myopathy #Muscle ... Statin-induced myopathy ... Cocaine-induced myopathy
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
Hypothyroid Myopathy ... hypothyroidism Pathophysiology ... Symmetric, proximal myopathy ... Rhabdomyolysis (rare) #Hypothyroid ... #Myopathy #pathophysiology
Hypothyroidism and Hyperthyroidism - Symptoms and Signs
Hypothyroidism:
 - General - From asymptomatic to myxedema coma, “Like
ophthalmoplegia) • ± Diffuse ... MSc @AmyChung #Hypothyroid ... #Hyperthyroid #
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
Hyperparathyroid - Hyperthyroid ... #Osteoporosis #pathophysiology
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... , hypothyroid-induced ... myopathy, Guillain-Barré ... Statin-induced myopathy ... - Necrotizing myopathy
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
hypertrophy, Proximal myopathy ... reflexes, Anaemia #Hypothyroid
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
and scaly skin, myopathy ... Myopathy due to ... endocrinology #hypothyroid
Hashitoxicosis

‘Leakage’ symptoms of active Hashimoto’s disease

- Hashitoxicosis (Htx) can occur during the initial hyperthyroid stage in
during the initial hyperthyroid ... Diffuse infiltration ... Endocrinology #Diagnosis #Pathophysiology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
Alopecia) - General (Diffuse ... Diagnosis Algorithm DIFFUSE ... contraceptives • Hyperthyroid ... Secondary syphilis #Diffuse
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
proximal weakness Myopathy ... mediated necrotizing myopathy ... Endocrinopathies: Hypothyroid