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hematology hemophagocytic lymphohistiocytosis treatment disease activation apml behcet calcium cerebritis cns cppd deposition differentiation erythematosus hemeonc leukostasis lupus lysis macrophage
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
) Pathophysiology ... Auto-amplification loop Diagnosis ... Lymphohistiocytosis #diagnosis ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... can mimic common infections ... Treatment: • Infection ... #management #treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lymphohistiocytosis (HLH ... SLE], AOSD) • Infection ... • HLH Labs: ... #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Triggers: â–ª Infections ... Pathophysiology ... underlying trigger: Infections ... #Management #Hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
common in Asia • HLA-B51 ... +/- myocardial infarction ... inhibitors • Uveitis- Ophthalmology ... #diagnosis #management ... signs #symptoms #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... ischemia, bowel infarction ... : • Pathophysiology ... #TLS #diagnosis ... #management #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Lupus Cerebritis Induction ... CNS #neurology #rheumatology ... #management #treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... : Infection (sepsis ... Differentiation #Syndrome ... #management #hematology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
vasculitis - Infectious ... fast bacterial infection ... cell lymphoma Pathophysiology ... Histopathological Diagnoses ... #management #rheumatology
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Disease (CPPD) Pathophysiology ... concomitant infection ... Crowned Dens Syndrome ... Deposition #Disease #Rheumatology ... #diagnosis #management
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