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diagnosis hemeonc hemophagocytic hlh lymphohistiocytosis oncology dermatology differential differentiation emergencies erythematous leukostasis lysis nikolsky oncologic rash tls treatment tumor
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Subacute-Acute: • Common: fever ... Rare: DAH, acute febrile ... #management #hematology
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
or absence of fever ... If fever is present ... disease, scarlet fever ... but without a fever ... #Nikolsky #Febrile
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... - 80% have fever ... Treatment: - If febrile ... TLS #diagnosis #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... acute or subacute febrile ... following: • Fever ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Neutropenic fever ... : - Fever + ANC ... ): - Hematologic ... or HSCT - CRS: fever ... therapy - Symptoms: fever
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
consideration in febrile ... Characteristics: Persistent fever ... Persistent high fever ... Fever b. ... #Hematology #HemeOnc
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