14 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... but often not specific ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Soluble antigen - Allergen-specific ... lgE antibodies ... - Local and systemic ... during hemolytic disease ... Diagnosis #Reactions #Table
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... #diagnosis #table ... #rheumatology # ... antibodies
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... , Others: SRP, Mi ... • Scleroderma (Systemic ... #associations #table
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... Association with disease ... erythematosus #diagnosis #rheumatology ... #table #ANA
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Mechanism of Action: Allergen-specific ... Action: IgG/lgM antibodies ... reaction, Haemolytic disease ... glomerulonephritis, Systemic
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... female, asian • Systemic ... relapse No specific ... autoantibodies (antinuclear antibodies ... workup #treatment #rheumatology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... antiphospholipid antibodies ... antiphospholipid antibodies ... associated with systemic ... #differential #hematology
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
features that are specific ... heart valves • MRI ... often seen • MRI ... - Infectious Diseases ... Marantic #diagnosis #table
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
specific for myeloperoxidase ... , such as systemic ... LFT • ESR • ANA ... ) pattern: antibodies ... differential #diagnosis #rheumatology