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diagnosis autoantibodies allergy classification hypersensitivity reactions ana antinuclear arthritis comparison disease erythematosus laboratory lupus management pathophysiology rheumatic rheumatoid sjogrens syndrome
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Associations ANA ... - Non-specific; ... Autoantibodies #Associations ... #table #rheumatology ... #antibodies
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... with disease activity ... erythematosus #diagnosis #rheumatology ... #table #ANA
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
lgE antibodies ... When the specific ... - Local and systemic ... during hemolytic disease ... Diagnosis #Reactions #Table
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
others (RNP, aPL antibodies ... , Others: SRP, Mi ... • Scleroderma (Systemic ... #diagnosis #associations ... #table
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Summary table of ... Action: Allergen-specific ... Action: IgG/lgM antibodies ... reaction, Haemolytic disease ... glomerulonephritis, Systemic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... Anti-Ro/SSA ab (specific ... IV RTA, TYPE I ... Central nervous system ... Sjogrens #Syndrome #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... double-stranded DNA antibodies ... which are more specific ... Tests for All Types
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