28 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... , TIF1y, NXP2, Mi ... #clinical #diagnosis ... #rheumatology # ... table
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
their Disease Associations ... ANA - Non-specific ... #diagnosis #table ... #rheumatology # ... antibodies
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
lgE antibodies ... When the specific ... during hemolytic disease ... Pathophysiology #Allergy #Diagnosis ... #Reactions #Table
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... but often not specific ... #Antinuclear #Antibodies ... #rheumatology #diagnosis
Commonly Used Diagnostic Tests for Celiac Disease

Tissue transglutaminase (tTG) IgA antibodies
 - Most reliable noninvasive test
Commonly Used Diagnostic ... Tests for Celiac Disease ... as sensitive or specific ... Laboratory #Tests #Diagnosis ... #Workup #Table
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... others (RNP, aPL antibodies ... , Others: SRP, Mi ... #diagnosis #associations ... #table
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Summary table of ... Action: Allergen-specific ... Action: IgG/lgM antibodies ... reaction, Haemolytic disease ... #allergy #table
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Table Warm AIHA ... (48-70%) Cold AHA ... Cold Agglutinin Disease ... Mixed-type AIHA ... #Table #hematology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... relapse No specific ... autoantibodies (antinuclear antibodies ... IgG4 #Related #Disease ... workup #treatment #rheumatology