11 results
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Myositis Specific ... , TIF1y, NXP2, Mi ... #clinical #diagnosis ... #rheumatology # ... table
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
lgE antibodies ... When the specific ... during hemolytic disease ... Pathophysiology #Allergy #Diagnosis ... #Reactions #Table
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Autoantibodies and their Disease ... Associations ANA - Non-specific ... #diagnosis #table ... #rheumatology # ... antibodies
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Association with disease ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
IgG4-Related Disease ... and relapse No specific ... autoantibodies (antinuclear antibodies ... #diagnosis #management ... workup #treatment #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Anti-Ro/SSA ab (specific ... IV RTA, TYPE I ... RTA Diagnosis: ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Shock and Vasoactive Drugs 
1) Determine type and etiology of shock
 • Distributive: Sepsis, Anaphylaxis, Neurogenic
1) Determine type ... Failure, Valvular Disease ... #inopressors #diagnosis ... #management #comparison ... #table
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... double-stranded DNA antibodies ... which are more specific ... Tests for All Types ... #testing #Rheumatology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Pager Summary Type ... determines blood type ... Blood Product Types ... #Transfusions #diagnosis ... #management #hematology
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
thorough history (specific ... Risk Stratify Type ... What is the type ... medical and surgical management ... stratification #diagnosis