6 results
Idiopathic Inflammatory Myopathies (IIM's)

RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's)

 • Overlap Myositis
• Overlap Myositis ... that occurs in association ... features of another autoimmune ... connective tissue disease ... IIMs #diagnosis #rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
their Disease Associations ... common in SLE, autoimmune ... microsomal) - Autoimmune ... Autoantibodies #Associations ... #table #rheumatology
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Inflammatory Myopathies ... Anti-MDA5, anti-Mi ... exclusion Necrotizing Autoimmune ... diagnosis #comparison #rheumatology ... #table
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ANA ... Peptide (CCP) • Myositis ... , Others: SRP, Mi ... #diagnosis #associations ... #table
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
of life Causes and ... clinical associations ... Autoimmune diseases ... Urticaria #diagnosis #rheumatology ... #comparison #table
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... Inflammatory Myopathies ... , drug-induced myopathies ... (also seen in association ... #rheumatology #