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diagnosis differential myositis ana antinuclear antinxp2 antinxp2dm autoimmune clinical comparison dermatology dermatomyositis diseases erythematosus inflammatory lupus management msas myopathies myopathy
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... others (RNP, aPL antibodies ... , Others: SRP, Mi ... diagnosis #associations ... #table
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... their Disease Associations ... diseases #diagnosis #table ... #rheumatology # ... antibodies
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific Antibodies ... , TIF1y, NXP2, Mi ... Myositis #Specific #Antibodies ... clinical #diagnosis #rheumatology ... #table
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... Anti-dsDNA 60-80% Association ... #Antinuclear #autoantibodies ... erythematosus #diagnosis #rheumatology ... #table #ANA
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
to 50X ULN • Autoantibodies ... Anti-MDA5, anti-Mi ... to 50X ULN • Autoantibodies ... diagnosis #comparison #rheumatology ... #table
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
• CK > 50 ULN Antibodies ... RP-ILD), dermato-rheumatologic ... (also seen in association ... Mechanic's hands Autoantibodies ... Myositis #Myopathy #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
without these autoantibodies ... • Antibodies targeting ... • Myoglobin Association ... diagnosis #management #rheumatology
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