6 results
diagnosis hematology anemia hemolysis hemolytic oncology agglutinin apml causes differentiation disease extravascular fever intravascular management monoclonal paraproteinemias pfapa
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Autoimmune: Warm AIHA, Cold ... Drug-associated, PCH, Evans Syndrome ... #Hemolysis #Differential ... #Diagnosis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... • Intrinsic RBC ... Extravascular #Causes #differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... Agglutinin Syndrome ... Blood smear - RBC ... younger pts) Differential ... hemolytic #anemia #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... initiation • Differential ... Differentiation #Syndrome ... diagnosis #management #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
capillary leak syndrome ... +Organomegaly+↑RBC ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential
PFAPA Syndrome - Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis EPIDEMIOLOGY: PFAPA is the most common syndrome entailing
PFAPA Syndrome - ... fever (FMF) PATHOPHYSIOLOGY ... DIFFERENTIAL DIAGNOSIS ... - Familial cold ... Serial CBC counts
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