9 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation ... Syndrome in APML ... ATRA treatment Pathophysiology ... initiation • Differential ... nsrosenberg #Differentiation
Asthma: immunopathogenesis. 
Allergens attach to, and are taken up by, dendritic cells that he the respiratory
attach to, and are ... cens leads to the differentiation ... B cells. which differentiate ... and release IgE ... immunopathogenesis #Pathophysiology
Petechiae/Purpura - Diagnostic Algorithm. Pathophysiology: 1) Represent the passage of erythrocytes from the intravascular to extravascular
Pathophysiology: ... 1) If lesions are ... manifestations are ... #Diagnosis #Dermatology ... Palpable #Algorithm #Differential
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders - Differential ... - Bimodal Age ... Classification #pathophysiology ... #Hematology #Diagnosis ... #NonHodgkin #differential
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
) are produced from ... : Ag-presenting ... • Differentiation ... proliferate and differentiate ... Humoral #Immunity #pathophysiology
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
liver disease) are ... common, there are ... myeloma, CML, AML ... deficiency #Ammonia #Pathophysiology ... Hyperammonemia #Differential
D-dimer
Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
increase with age ... i.e. 80 yrs of age ... - Age (yrs) x 10 ... Ddimer #dimer #pathophysiology ... #hematology #differential
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Band neutrophils are ... Neutrophil (Normal) Differential ... #Bandemia #differential ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
• Mean age at Dx ... transformation to AML ... blood count with differential ... progression to AML ... Syndromes #diagnosis #hematology