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diagnosis management causes differential secondary signs 21hydroxylasedeficiency adrenal alkaline alp bulimianervosa complications emergencies genetics hematology hemeonc hepatology high hyophosphatasia hyperparathyroidism
Causes of Hypercalcemia Hypercalcemia due to increased bone Ca2+ resorption: • Primary hyperparathyroidism, Malignancy, Pseudohyperparathyroidism, Renal failure,
resorption: • Primary ... histoplasmosis) • Milk (calcium ... )-alkali syndrome ... differential #diagnosis #calcium ... #high #endocrinology
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Comparison: • Primary ... Phosphate Physical Symptoms ... pain Psychiatric Symptoms ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
Signs/Symptoms/Complications ... Hirsutism & acne • Infertility ... #21HydroxylaseDeficiency #21OHD ... #pathophysiology ... #genetics #endocrinology
Causes of Hypercalcemia Parathyroid gland structure-related • Primary hyperparathyroidism • Parathyroid adenoma • Parathyroid hyperplasia • Parathyroid
Causes of Hypercalcemia ... structure-related • Primary ... Lithium use • Calcium-sensing ... • Milk-alkali syndrome ... #Causes #endocrinology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... changes, stroke symptoms ... : • Pathophysiology ... hydration - Hyperkalemia
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... fibrosis. 4) Calcium ... hyperphosphatemia, hypercalcemia ... mediators such as hypercalcaemia ... patients) and/or hypercalcuria
Adrenal Insufficiency - Diagnosis and Management Summary Primary Adrenal Insufficiency: Most Common Cause in the US: Autoimmune Adrenalitis Other
Management Summary Primary ... ketoconazole, etomidate) Symptoms ... Hyperkalemia is ... hypophysitis, Sheehan's syndrome ... Diagnosis #Management #Endocrinology
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
collection with EDTA Pathophysiology ... ALP -> PPi and Calcium ... mineralization Symptoms ... Hyperlipidemia - Hypercalcemia ... • Elevation of urinary
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
Lower-extremity weakness, urinary ... plasmapheresis Hypercalcemia ... malignancy: - Calcium ... /dL → treat - Calcium ... → treat - Calcium
Bulimia Nervosa: Complications GASTROINTESTINAL • Dehydration & inability to digest food -> Constipation • Recurrent vomiting exposes
• Boerhaave syndrome ... > Amenorrhea & Infertility ... Calcium, VitD) and ... Complications #pathophysiology ... diagnosis #signs #symptoms
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