27 results
syndrome disease blood causes dermatology differential hemophagocytic hlh lymphohistiocytosis neurology oncology product reactions stills acquired activation adult adultonset anemia antinxp2
Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Diagnosis of TTP: • Rare and severe, ADAMTS13 deficiency • Autoimmune
Purpura (TTP) Diagnosis ... severe, ADAMTS13 deficiency ... Thrombocytopenic #Purpura #management ... #treatment #rheumatology ... #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Willebrand Syndrome - Diagnosis ... and Management ... vonWillebrand #Syndrome #Diagnosis ... #Management #treatment ... #hematology #differential
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
and Management ... hemophilia type (e.g ... Avoid meds that ... #Management #treatment ... #hematology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... mevalonate kinase deficiency ... Stills #Disease #diagnosis ... #management #treatment ... #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
permeability Diagnosis ... Lumbar Puncture, EEG ... Treatment: ... CNS #neurology #rheumatology ... #management #treatment
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
with response to treatment ... Glucocorticoids (0.6 mg/kg ... #management #phenotypes ... #workup #treatment ... #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... Low calcium • Treatment ... unless worrisome EKG ... Syndrome #TLS #diagnosis ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Cellular immune deficiency ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Prednisone 5mg/kg ... opacities • Diagnosis ... Renal Failure Treatment ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Infection (eg ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
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