12 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome in APML ... Triggers: ATRA treatment ... effusions, weight gain ... initiation • Differential ... diagnosis #management #hematology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... spine, shoulders, hips ... #Differential # ... Diagnosis #MSK # ... rheumatology #Monoarticular
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... Responsive to Treatment ... Treated Like Acute ... Amy Chung, MD, MSc ... pathophysiology #Hematology
Leg Pain - Differential Diagnosis Framework

Bone/Joint Causes of Leg Pain:
 • Fracture
 • Arthritis
 • Gout/pseudogout
Leg Pain - Differential ... Immobilization) • Acute ... #differential # ... lower #extremity #msk ... #physicalexam
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Approach to Joint Pain ... Arthritis: • Acute ... e.g., congenital hip ... #MSK #rheumatology ... approach #workup #differential
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Knee Effusions - Differential ... Fever/Chills/Joint pain ... Reactive Syndrome - Acute ... #diagnosis #msk ... #physicalexam
Anterior Non-necrotizing Scleritis - Slit Lamp Ocular Examination

This 57 yo WM reported to clinic complaining of
he reported no pain ... using a cotton tip ... scleritis, which came ... treatment. ... ophthalmology #physicalexam
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint Pain ... Like in this case ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Petechial Rash - Differential ... hemorrhage, which are ... lesions • Severe pain ... for hepatitis B and ... #physicalexam
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
are dysfunctional ... Agent Orange or Hep ... microglobulin Treatment ... ’s lymphoma or acute ... workup #oncology #hematology