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differential lupus management ana antibodies antinuclear autoantibodies erythematosus sle systemic associations definition dermatology druginduced endocarditis infarction infective inflammatory marantic ms
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
, TIF1y, NXP2, Mi ... Anti-Synthetase Syndrome ... Antibodies #MSAs #clinical ... #diagnosis #rheumatology ... #table
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... Peptide (CCP) • Myositis ... , Others: SRP, Mi ... #diagnosis #associations ... #table
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Anti-MDA5, anti-Mi ... Necrotizing Autoimmune Myositis ... Inclusion Body Myositis ... #comparison #rheumatology ... #table
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Demyelinating syndromes ... Glomerulonephritis Myositis ... signs #symptoms #diagnosis ... #rheumatology
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
features that are ... heart valves • MRI ... often seen • MRI ... #Endocarditis #comparison ... #table
Differentiating type-I vs. type-II MI Sorting this out is difficult, often relying heavily on clinical judgement. A key
relying heavily on clinical ... The table below ... #Diagnosis #Myocardial ... Definition #NSTEMI #Comparison ... #Table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
likely it will be clinically ... SLE), Sjogren's Syndrome ... , Myositis, Mixed ... ANA #patterns #rheumatology ... #diagnosis #differential
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
a rare chronic ... Rheumatic pain Clinical ... : • A clinical ... - MRI: inflammation ... #Rheumatology #
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
-15% If SLE is clinically ... SLE-SSc-AlM overlap syndromes ... erythematosus #diagnosis ... #rheumatology # ... table #ANA
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