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diagnosis clinical blood hematology path smear causes dermatology algorithm classification purpura skin asplenia blurry bruising calculation cellulitis codocytes cutaneous dacrocytes
Dacrocytes (tear drop cells) Other poikilocytes resemble a pear or teardrop. The narrow, tapered end may be
each of the above photos ... Dacrocytes are found ... thalassemia, and some hemolytic ... anemias. ... Clinical #Path #BloodSmear
Schistocytes - The arrows point to schistocytes which are fragmented red blood cells. Also called schizocytes,
In the right photo ... anemias, especially ... anemia in which ... is mechanical trauma ... Clinical #Path #BloodSmear
Codocytes (Target cells) - Two target cells are seen in the left photo and one in
seen in the left photo ... present in the left photo ... associated with hemolytic ... anemias, especially ... Clinical #Path #BloodSmear
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
• Mechanical Trauma ... anemia): ... lactam antibiotics are ... Extravascular #Causes #differential ... diagnosis #hematology #anemia
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... Acute blood loss: Trauma ... Retroperitoneal, Uterine • Hemolysis ... Microangiopathic hemolytic ... #differential #
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... anemia, PNH, immune ... - Pernicious anemia ... Demand ischemia • Trauma ... Dehydrogenase #Elevated #differential
Spherocytes - The arrow points to one of many spherocytes in this photo. The cells have
spherocytes in this photo ... spherocytosis and hemolytic ... anemias. ... When spherocytes are ... Clinical #Path #BloodSmear
Sickle cells These photos show sickle cells on peripheral blood smears. In the left photo target cells
In the left photo ... target cells are ... no significant anemia ... sickle unless they are ... Clinical #Path #BloodSmear
Howell-Jolly Body - On these Wright-stained peripheral blood smears the small dark spheres within red cells
poikilocyte in the left photo ... cells in the right photo ... can be found in hemolytic ... anemia. pernicious ... Clinical #Path #BloodSmear
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... blood loss, Acute hemolysis ... , deficiency anemia ... infarction, Severe trauma ... Thrombocytosis #Platelets #Differential
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