13 results
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... patients who have treatment-resistant ... Most metabolites are ... #Toxicology #Toxicity ... #Diagnosis #Pharmacology
Intravenous Lipid Emulsion (ILE) Therapy

ILE is a treatment for severe toxicity from local anesthetics. In addition,
Therapy ILE is a treatment ... for severe toxicity ... life-threatening toxicity ... #ILE #Therapy #Toxicology ... #Management #Pharmacology
Second Generation Antipsychotics: Mechanisms and Side Effects
(Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Anti-Psychotics) - Examples: Clozapine ... binding affinities are ... Clozapine is considered ... considered 2nd line treatment ... #SideEffects #pharmacology
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
dose (trough) Clozapine ... at anytime if toxicity ... Therapeutic #Ranges #Toxicology ... #Pharmacology #
Drug-Induced Prolonged QTc

QTc >500ms is an independent risk factor for developing Torsades des Pointes (TdP)
Drugs causing
Chlorpromazine, Clozapine ... Prolonged #QTc #Toxicity ... #Toxicology #Pharmacology
Testicular Cancer - Treatment Related Toxicities

Bleomycin, Cisplatin, Etoposide, lfosfamide
Tinnitus & Hearing Loss
Neurotoxicity
Pulmonary Fibrosis
Hypotension
Nephrotoxicity
Skin Hyperpigmentation
Hemorrhagic Cystitis
Myelosuppression
Peripheral Neuropathy

Ashley
Testicular Cancer - Treatment ... #chemotherapy #toxicity ... #toxicology #Toxicities ... #pharmacology #
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
starting amiodarone treatment ... distress syndrome) is rare ... macrophages Treatment ... • Favorable in case ... diagnosis #management #Toxicology
Methotrexate Toxicology 

Intravenous leucovorin (folinic acid) treatment serves as a cofactor necessary for synthesis of thymidylate
Methotrexate Toxicology ... (folinic acid) treatment ... evidence of marrow toxicity ... #Toxicity #Management ... #Pharmacology
Fomepizole for Acetaminophen Toxicity

 • In cases where fomepizole and NAC were administered together, evidence has
Acetaminophen Toxicity ... has come from case ... Acetaminophen #Toxicology ... #pharmacology #
Tramadol - Toxicology
Due to different CYP-2D6 genotypes, people variably metabolize tramadol into its active metabolite, M1
This
Tramadol - Toxicology ... - Some people are ... #Tramadol #Toxicology ... #Toxicity #Diagnosis ... #Pharmacology