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management oncology differential hemophagocytic hlh lymphohistiocytosis algorithm causes mds myelodysplastic anemia apml band calcium cancer chronic clinical cll cppd deposition
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... infarction, Severe trauma ... #Algorithm #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Conservative/supportive care ... only curative treatment ... #Management #treatment ... #hematology #oncology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... • Mechanical Trauma ... ) - HELLP syndrome ... lactam antibiotics are ... #hematology #anemia
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Renal Failure Treatment ... • Supportive Care ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... adenopathies, confusion ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... • Bicytopenia Treatment ... insulting agent are ... #management #treatment ... #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
a rare chronic ... and lower jaw Treatment ... #Rheumatology # ... diagnosis #management ... #Dermatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
large numbers and are ... phenomenon CLL Diagnosis ... microglobulin Treatment ... • Richter’s Syndrome ... workup #oncology #hematology
Iliotibial Band Friction Syndrome - MSK Radiology Imaging Findings: • The iliotibial band (ITB) is thickened with
Band Friction Syndrome ... Case description ... • Treatment: Conservative ... • Direct trauma ... /contusion: Soft-tissue
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