2859 results
One and a Half Syndrome on Physical Exam

This 28 year old patient presented to clinic with
One and a Half Syndrome ... Cogan’s) One and a Half ... one side and an internuclear ... OneAndAHalf #One #Half
Pharmacology of diuretics

Acetazolamide, Loop diuretics, Thiazide‐like diuretics, MRA, Amiloride

Site of Action, Maximum Dose, Half-Life, Onset, Bioavailability,
Maximum Dose, Half-Life ... CHF #Cardiology #Management
Wall-eyed bilateral inter nuclear ophthalmoplegia (WEBINO) Syndrome

In this specific case, the lesion is bilaterally in the
Walleyed #bilateral #internuclear
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
to transiently halt ... Diabetes Mellitus Half-and-Half
SSRI Initiation
How long before increasing dose?
 • 4 wks. Initial response in 2-4 wks, max response
GAD-7 Longest half ... Shortest half life ... psychiatry #treatment #management
One-and-a-Half Syndrome
1 - One eye cannot move AT ALL horizontally
1/2 - The other eye can only
One-and-a-Half Syndrome ... abduct (can do only half ... OneAndAHalf #One #Half
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
44: Initiate at half ... titrate upwards to half ... pharmacology #algorithm #management
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
syndromes such as internuclear ... Lhermitte’s sign • Internuclear ... sclerosis #diagnosis #management
Trichodysplasia spinulosa: follicles plugged w/ hyperkeratotic & parakeratotic debris, excessive inner root sheath differentiation towards keratinization.
EM shows intranuclear
Amiodarone Toxicity and Monitoring

Tremor Ataxia 
Ocular neuritis 
Corneal Microdeposits 
Bradycardia 
Pulmonary fibrosis 
Hepatotoxicity 
Blue-gray skin
Distribution - Half ... Adverse #Diagnosis #Management