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Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
for Hemolysis - Intravascular ... Causes Intravascular ... Microangiopathic hemolytic anemia ... #Causes #differential ... diagnosis #hematology #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... and Intravascular ... PK deficiency Intravascular ... immune-complex hemolytic anemia ... Diagnosis #Algorithm #Causes
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
for Hemolytic Anemia ... Intrinsic Causes ... IVIG infusion Intravascular ... Causes: • MAHA ... #Hemolytic #Anemia
Causes of Wide Pulse Pressure - Differential Diagnosis Physiologic: • Advanced age-arteriosclerosis (less compliant arteries) • Well
Causes of Wide Pulse ... conditions) • Severe intravascular ... iron deficiency anemia ... viscosity) - anemia ... Differential #Diagnosis #causes
Causes Abnormal Urine Color - Differential Diagnosis Turbid White Urine (Albinuria): • Chyluria, Filariasis, Schistosomiasis, Malignancy, Phosphaturia,
Causes Abnormal ... Syndrome - UTI caused ... UTI, Porphyria, Intravascular ... deficiency, sickle cell anemia ... Furazolidone, Intramuscular
Evaluation of Patients with Anemia Microcytic, Normocytic, Macrocytic, Hemolytic (Intravascular and Extravascular) #Diagnosis #Anemia #Workup #Macrocytic #Microcytic #Normocytic
Patients with Anemia ... Macrocytic, Hemolytic (Intravascular ... and Extravascular ... #Diagnosis #Anemia
Laboratory Testing in Hemolytic Anemia Intravascular vs Extravascular Hemolysis Reticulocytes Unconjugated bilirubin LDH Peripheral smear Haptoglobin Urine hemosiderin Urine hemoglobin Carboxyhemoglobin #Hemolytic #Anemia #Laboratory #Testing #workup
Testing in Hemolytic Anemia ... Intravascular ... vs Extravascular ... #Hemolytic #Anemia
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency Anemia ... • Iron loss: Intravascular ... (not extravascular ... Iron #Deficiency #Anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Sideroblastic anemia ... Megaloblastic anemia ... , Pernicious anemia ... , Disseminated intravascular
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... breakdown • Anaemia ... Hemolysis #Hemolytic #Anemia ... #Differential #Causes
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