1005 results
Melanoma Pathogenesis

Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
growth, tumour invasion ... #Pathophysiology
Trachoma: Pathogenesis and clinical findings

 • Environmental Factors -> Bacterial infection is encouraged by poor hygiene
papillae -> Pannus (invasion ... Trachoma #Chlamydia #pathophysiology
Acute Otitis Externa (Swimmer’s Ear): Pathogenesis and clinical findings
Pathogens = Pseudomonas aeruginosa (most common opportunistic), Staphylococcus,
soft tissue -> Invasion ... #SwimmersEar #pathophysiology
Pathogenesis of meningitis 

Risk factors for pathogen entry include immunocompromised state (HIV positive, cancer, chemotherapy patients,
Following pathogen invasion ... #Meningitis #Pathophysiology
Diabetic Foot: Pathogenesis and clinical findings
 • Polyol Pathway - Excess glucose enters Polyol pathway ->
result of WBC invasion ... #DiabeticFoot #pathophysiology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
HIV dementia Pathophysiology ... fluid-attenuated inversion
Calcium Channel Blocker Conversion Table

Nifedipine versus amlodipine - Nifedipine XL used only as the short acting
Channel Blocker Conversion ... the short acting version ... CalciumChannelBlocker #Conversion
Wellens' Sign: LAD-T Wave Inversion 
Life threatening T wave inversions in precordial leads. Often V2-V3 
Specific
Sign: LAD-T Wave Inversion ... threatening T wave inversions
The Cardiac Cycle Animated - Systole, Diastole, Pressures and Volume - (slowed down version @ 1/2
- (slowed down version ... 1/2 speed) #Pathophysiology
Cyanide Toxicity 
Treatment:
1) Hydroxocobalamin + Cyanide = Cyanocobalamin (nontoxic) 
   or 
2) Amyl nitrite
thiosulfate enhances conversion ... Toxicity #Toxicology #Pathophysiology