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Sarcoidosis Non-caseating granulomas (Composed of T-helper & inflammatory cells) Clinical: • Disease fatal in 10% of
inflammatory cells) Clinical ... extensive organ involvement ... Sarcoidosis #Diagnosis #Symptoms
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
in GBA1 gene Clinical ... • Neurological involvement ... Diagnosis #Signs #Symptoms
Osteosarcoma Most common primary malignant bone tumor in children Most Common Sites of Involvement: 1. Distal femur
Common Sites of Involvement ... proximal femur Clinical ... injury • Systemic symptoms
Pott's Disease in Tuberculosis - Diagnosis and Management Summary Epidemiology: - Typically from TB endemic areas -
extrapulmonary cases Clinical ... Signs/Symptoms: ... back pain - Symptoms ... May have signs/symptoms ... concomitant pulmonary involvement
Clinical Effects of Large and Small Pituitary Tumours Local complications - Headache, Visual field defect, Disconnection hyperprolactinaemia,
Clinical Effects ... cavernous sinus involvement ... Tumors #Signs #Symptoms
Kawasaki Disease: Clinical Findings Diagnostic Criteria - Fever and 4/5 of the following: • Conjunctivitis • Polymorphous
Kawasaki Disease: Clinical ... lymphadenopathy • Mucosal involvement ... feet Signs/Symptoms ... Pathophysiology #Signs #Symptoms
Bullous Pemphigoid - Diagnosis and Management Summary Pathophysiology: Autoantibody-mediated damage to epithelial basement membrane -> separation of
epidermis from dermis Clinical ... Signs/Symptoms/ ... Mucous membrane involvement
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Autoimmune diseases • Clinical ... - B symptoms ... Noncontiguous spread • Clinical ... neuro, cutaneous involvement ... Diagnosis of B-Symptoms
Psoriatic Arthritis: Pathogenesis and Clinical findings In tendons and connective tissues: • Enthesitis - Pain/tenderness over
Pathogenesis and Clinical ... Axial involvement ... diagnosis #signs #symptoms
Symptoms Distinguishing Groups of Cutaneous Drug Reactions IgE-mediated reactions: • Onset minutes to hours into treatment course
Symptoms Distinguishing ... Mucosal and/or Organ involvement ... #dermatology #clinical
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