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diagnosis hematology algorithm differential management oncology aplastic workup mds myelodysplastic pancytopenia rbc rheumatology syndrome treatment aaa aorta atlas autoinflammatory bloodcell
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... vs Hypocellular MDS ... #Aplastic #Anemia
Approach to Hypoproliferative Macrocytic Anemia • 812, Folate Deficiency • MDS+ • Hypothyroid • Liver Disease
Hypoproliferative Macrocytic Anemia ... Deficiency • MDS ... #Macrocytic #Anemia
Common RBC Inclusions and Associations • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia • Heinz
Severe hemolytic anemia ... Sideroblastic anemia ... , Hemolytic anemia ... , Sickle cell, MDS
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Sideroblastic anemia ... ACD, Aplastic anemia ... Reticulocytosis, MDS ... MatthewHoMD #Anemia
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... • Symptomatic anemia ... megaloblastic anemia ... Can progress to MDS ... SCVMCMed #Aplastic #Anemia
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Iron deficiency anemia ... Chronic disease anemia ... Sideroblastic anemia ... Liver Disease, MDS ... iron deficiency anemia
5 D's Mnemonic for Causes of Iron Deficiency Anemia (IDA) Diet - lacking iron, vitamin C, too
Iron Deficiency Anemia ... pregnancy, urinary, lactation ... stevenbollipo #5Ds ... Iron #Deficiency #Anemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
cytopenias (usually anemia ... Myelodysplastic #Syndrome #MDS
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Abnormalities: macrocytic anemia ... myelodysplastic syndrome (MDS ... myelodysplastic syndrome (MDS
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