31 results
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... → Hypokalemia Metabolic ... #Syndrome #Pathophysiology
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Syndrome: Distal ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... , Gitelman Syndrome ... , Liddle syndrome ... #Primary #Metabolic ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... , Gitelman Syndrome ... , Liddle syndrome ... aldosteronism #Metabolic ... Diagnosis #Algorithm #Nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Low intake • Metabolic ... Renal Losses: • Metabolic ... SAME, Cushing Syndrome ... , Gitelman syndrom ... potassium #low #nephrology
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Urinary Chloride • Cl ... Kidney loss of Cl ... - Loss of Cl ... diuretic use, Bartter syndrome ... , Gitelman syndrome
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Chloride Algorithm Cl ... Kidney loss of Cl ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... urine #Algorithm #nephrology
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
acid, Liddle's Syndrome ... R - Cushing's syndrome ... Diuretics, Bartter's syndrome ... , Gitelman's syndrome ... Diagnosis #Algorithm #nephrology
Approach to Elevated Bicarbonate (HCO3)
Risk Factors for Hypercapnea? (Hx of COPD, OSA, sedative use, CNS/muscular disorders?)
(+)
Gas) (-) Likely Metabolic ... Contraction Urine Cl ... Barter, or Gitelman ... Syndrome Unremarkable ... Bicarbonate #Elevated #metabolic
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
transporter Bartter syndrome ... ascending limb Gitelman ... syndrome - Thiazide-sensitive ... tubule Liddle syndrome ... Defects #Kidney #Nephrology