21 results
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Tests (LFTs) - ... Differential Diagnosis ... • NAFLD • Cirrhosis ... Hepatopathy • Acute ... Viral Hepatitis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... months without treatment ... disease, liver ... #management #diagnosis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... > 20x normal - Acute ... CMV), Alcoholic cirrhosis ... #LFTs #transaminitis ... #differential #diagnosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Cholestatic disease ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... • Others #LFTs
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Algorithm Malignant ... Non-Malignant • Fatty Liver ... Hemochromatosis • Wilson's Disease ... Primary Biliary Cirrhosis ... #Hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Diagnosis Hepatocellular ... , Acute biliary ... #Differential #Diagnosis ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... HELLP, Celiac disease ... #hepatology #algorithm ... Transaminitis #LFTs ... #hepatitis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... disease: > 2 ... : < 1 • Cirrhosis ... #chemistry #diagnosis ... transaminitis #LFTs
Hepatobiliary Manifestations of Sickle Cell Disease
Acute sickle cell hepatic crisis:
 • Fever, acute onset RUQ pain,
of Sickle Cell Disease ... Supportive with treatment ... Hepatobiliary #hepatology ... #hepatitis #differential ... #diagnosis
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
B - Diagnosis and ... Management Algorithm ... viremia or have cirrhosis ... #HBV #Algorithm ... #Treatment #Hepatology