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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Injury (DILI) ... presentation • Chronic ... disease 6-9 mo ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... disease, liver ... Injury (DILI) ... #ACLF #Acute #Chronic ... Cirrhosis #Hepatology #gastroenterology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... • NASH, Chronic ... : > 3 • Chronic ... differential #diagnosis #algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... disease, Hepatic ... dechallenge • Acute or chronic ... e.g. ascites), Chronic ... #Algorithm #hepatology
Perianal Crohn's Disease - IBD Algorithm

 • 5-40% w perianal fistula
 • ↑ risk if colonic
Perianal Crohn's Disease ... - IBD Algorithm ... medical therapy • Chronic ... Perianal #Crohns #Disease ... #gastroenterology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Differential Diagnosis Algorithm ... • Anemia of Chronic ... Renal Disease, Liver ... Reticulocytosis • Liver ... Differential #Diagnosis #Algorithm
Non-ACS Myocardial Injury - Elevated Troponin Differential Diagnosis and Workup Algorithm

 • Chronic Myocardial Injury: End
Diagnosis and Workup Algorithm ... • Chronic Myocardial ... Renal Disease, ... Structural Heart Disease ... (ie Sarcoid), Chronic
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
The Liver Consult ... Focus on prior Liver ... current MELD - Chronic ... liver disease work ... Referral #Hepatology #Gastroenterology
Upper GI Bleed - Management Algorithm

Upper GI bleed Suspected: Melena, hematemesis, coffee-ground emesis, BRBPR
Initial Stabilization
Concern for
Bleed - Management Algorithm ... Disease Consult ... • Peptic Ulcer Disease ... GAVE (idiopathic, liver ... gastrointestinal #gastroenterology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injuryliver ... Hemochromatosis, Wilson's disease ... HELLP, Celiac disease ... Diagnosis #hepatology #algorithm