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diagnosis differential management spinalcord algorithm disorders hematology signs spinal syndromes treatment acute als alzheimersdisease amyotrophic barre cauda caudaequina causes classification
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Syndrome ->Cord ... #diagnosis #pathophysiology ... #signs #symptoms ... #msk #orthopedics ... #neurology
Lesions of the Spinal cord - Spinal Cord Syndromes Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... result in permanent neurologic ... injury - Multiple sclerosis ... Lower motor neuron symptoms ... Upper motor neuron symptoms
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
• Or brainstem syndromes ... Signs and symptoms ... (Spinal cord predominant ... objective evidence of neurologic ... diagnosis #management #neurology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
findings: • Symptoms ... : - Multiple sclerosis ... Scleroderma, Systemic sclerosis ... MCTD, Sjogren syndrome ... disorders #diagnosis #neurology
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Risk factor for Late ... mutations - Down syndrome ... memory • Aphasia, word-finding ... AlzheimersDisease #Dementia #pathophysiology ... diagnosis #signs #symptoms
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Hyperreflexia develops later ... Bilateral signs and/or symptoms ... : - Multiple sclerosis ... diagnosis #management #neurology
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
spine L1-L5 Symptoms ... so-called ‘red flag’ symptoms ... Diagnosis: • Spinal cord ... spondylitis • Tethered cord ... diagnosis #causes #neurology
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
meninges in spinal cord ... nerve roots Spinal Cord ... Reconstitution Inflammatory Syndrome ... the tuberculoma (later ... differential #TB #neurology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Classic - Nodular Sclerosis ... pattern of spread, B symptoms ... very high mitotic rate ... Amy Chung, MD, MSc ... Classification #pathophysiology
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Pathophysiology ... multiple spinal cord ... features developing later ... fasciculations Common Symptoms ... #neurology #diagnosis
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