11 results
Biphasic Illness of Leptospirosis
Some patients do not progress to severe disease. Others, rapidly develop severe disease
Biphasic Illness ... -14 days): • Fever ... maculopapular rash ... Washington University ID ... #Diagnosis #Illness
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... : High spiking fever ... maculopapular rash ... : high fever, CRP ... #management #treatment
ID Approach to Fever and Rash - Diagnostic Algorithm
Central Maculopapular (most common):
Measles, Parvovirus 819 / EBV,
ID Approach to Fever ... and Rash - Diagnostic ... WNV, Mycoplasma, Leptospirosis ... angiomatosis, Sweet syndrome ... #Rash #Febrile
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... Biphasic Fever ... • Leptospirosis ... • Malaria • Leptospirosis ... #Differential #Diagnosis
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... with urticarial rash ... #Adult #onset #Stills ... #disease #AOSD ... #management
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
• Adult-onset Still ... - Nonremitting fever ... Petechial or purpuric rash ... erythematosus [SLE], AOSD ... #Diagnosis #Management
Hantavirus
Pathogen: Hantavirus - Rodents are the primary reservoir
Transmission:
 • Shed in the urine, feces, saliva of
Cardiopulmonary Syndrome ... • Prodrome: fever ... , chills, myalgias ... #management #treatment ... #microbiology #
Disseminated Gonococcal Infection - Diagnosis and Management Summary

Bacteremic spread of the Gram-negative diplococci Neisseria gonorrhoeae. History
and Management ... Arthritis-Dermatitis syndrome ... : • Fever, chills ... Purulent Arthritis Syndrome ... #Management #Microbiology
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS) Microbiology ... Generalized: • Chills ... night sweats, fever ... Persistent bacteremia/fevers ... #management #cardiology
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Hypercoagulable (APLAS) Microbiology ... Generalized: Chills ... night sweats, fever ... Cholesterol emboli syndrome ... Persistent bacteremia/fevers