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management infectiousdiseases rheumatology differential disease adultonset aosd activation adult canimorsus capnocytophaga cardiology chronic clinical cll dermatology endocarditis gangrenosum hantavirus hemophagocytic
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... endocarditis, malaria • Leptospira ... • Leptospirosis ... • Malaria • Leptospirosis ... #Differential #Diagnosis
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... susceptibility, infectious ... : High spiking fever ... #AdultOnset #Stills ... #treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Clinical triad: Fever ... : • Infectious ... #management #treatment ... #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Treatment - Mild ... : NSAIDS Treatment ... #Adult #onset #Stills ... #rheumatology #
Hantavirus Pathogen: Hantavirus - Rodents are the primary reservoir Transmission: • Shed in the urine, feces, saliva of
common route of infection ... • Prodrome: fever ... , chills, myalgias ... +/- diarrhea Diagnosis ... #microbiology #
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... +, Adult-onset Still ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Capnocytophaga Pathogen: Capnocytophaga • 9 species, C. canimorsus responsible for the majority of infections • Gram-negative rod,
the majority of infections ... • Cellulitis: Fever ... , Chills, General ... Treatment: • 50% ... Capnocytophaga #canimorsus #microbiology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
: • Leptospirosis ... cases of malaria diagnosed ... with headache, chills ... Zika virus or leptospira ... #Differential #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... weeks without infection ... lymphocyte > 5000/microL ... microglobulin Treatment ... workup #oncology #hematology
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