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management hematology infectiousdiseases disease hemophagocytic hlh lymphohistiocytosis american chagas chronic cll hemeonc hodgkins leukemia lymphocytic lymphoma syndrome trypanosomiasis activation acute
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... : fever +++, hepatosplenomegaly ... #management #treatment ... #summary #rheumatology
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... triad: Fever, Arthralgia ... : • Infectious ... #management #treatment ... #rheumatology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... ) B symptoms → fevers ... Complications: 1) Infection ... Lymphocytic #Leukemia #oncology ... #hematology #hemeonc
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: Overwhelming clinical ... can mimic common infections ... following: • Fever ... : • Infection ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... : Infection (sepsis ... Renal Failure Treatment ... #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
e.g., HIV), EBV infection ... - Pel-Ebstein fever ... Etiology: - Infections ... NonHodgkins #comparison #oncology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia Clinical ... Presentation: • Fever ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
respiratory symptoms • Fever ... pulmonary symptoms • Rheumatologic ... has five major clinical ... • Cough, fever ... fungal stain of clinical
Cyclosporiasis - Diagnosis and Management Summary Pathogen: • Cyclospora cayetanensis • Foodborne, waterbone, and soil-transmitted. •
transmission as zoonotic infection ... diarrhea, Low-grade fever ... routine O&P • Clinical ... #management #treatment ... #microbiology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
is the main clinical ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Rheumatology
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