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hemophagocytic hlh lymphohistiocytosis oncology syndrome treatment chronic differential hemeonc leukemia lymphocytic rheumatology workup abnormal activation algorithm anemia aplastic apml classification
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Clinical Features: Fever ... d-dimer, ↓ NK cell ... ): Molecular diagnosis ... : • Fever • Splenomegaly ... #hematology #criteria
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Consider stem cell ... if neutropenic fever ... #management #treatment ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... Physical Exam/Signs ... Diagnosis: • ... Lymphocytic #Leukemia #diagnosis ... workup #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... ) B symptoms → fevers ... Leukemia #oncology #hematology ... #hemeonc #diagnosis ... #management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: HLH signs and ... following: • Fever ... Low or absent NK cell ... #management #treatment ... #hematology
Fever in the Returning International Traveler Investigations after comprehensive physical examination including thorough skin examination: •
Arbovirus Empiric Management ... the following criteria ... hours; AND 4) All ... #empiric #management ... #workup #diagnosis
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
and Management ... Criteria: • Elevated ... present, symptoms, signs ... #Management #Summary ... #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Periodic fever ... - Nonremitting fever ... Histopathologic criteria ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Diagnostic Criteria - 2004 vs 2009 At least three of the following: -
Lymphohistiocytosis (HLH) Diagnostic ... Criteria - 2004 ... following: - Fever ... Lymphohistiocytosis #Diagnosis ... #Criteria #Hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
- 80% have fever ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
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