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rheumatology disease hemophagocytic lymphohistiocytosis oncology syndrome aplastic chronic cll hemeonc kawasaki leukemia lymphocytic pediatrics summary symptoms activation adult algorithm aosd
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Clinical Features: Fever ... : ↑↑ ferritin, Anemia ... Criteria for HLH ... : • Fever • Splenomegaly ... #hematology #criteria
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... Treatment: • Consider ... if neutropenic fever ... #diagnosis #management ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: HLH signs and ... following: • Fever ... • Bicytopenia Treatment ... #management #treatment ... #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
with leukopenia, anemia ... Histopathologic criteria ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Presentation • Common Signs ... - Cytopenias (anemia ... Diagnostic Criteria ... criteria or a molecular ... #Management #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... • Clinical: fever ... Unknown cause Treatment ... #management #treatment ... #summary #rheumatology
Kawasaki Disease (KD) - Diagnosis and Management Summary Kawasaki Disease (KD) is the most common vasculitis of
and Management ... Presentation: • Fever ... Criteria - Fever ... KD #vasculitis #rheumatology ... #management #treatment
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
and Management ... Criteria: • Elevated ... present, symptoms, signs ... #Management #Summary ... #treatment #hematology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
Oroya Fever Hematologic ... severe hemolytic anemia ... Nodular → Mular DIAGNOSIS ... TREATMENT: ​• Acute ... #diagnosis #management
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
- Yamaguchi criteria ... Treatment - Mild ... : NSAIDS Treatment ... #rheumatology # ... management
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