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diagnosis rheumatology differential lupus management syndrome classification erythematosus pathophysiology systemic behcet complications cryoglobulinemia cryoglobulins disease manifestations mucocutaneous myelitis neurology primary
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
Primary Sjogren’ ... Pathogenesis and Clinical ... erythematosus (SLE ... ) Signs / Symptoms ... Xeroderma (Dry skin
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... (15%) Skin (85% ... Butterfly rash, Vasculitis ... erythematosus #signs ... #symptoms #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... Syndrome: • Clinical ... reticularis & skin ... Henoch-Schönlein purpura) • Cutaneous ... erythematosus (SLE
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
aphthous ulcers, cutaneous ... Presentation - Systemic Symptoms ... purpura: strong sign ... of cutaneous leukocytoclastic ... , and SLE) • Urinalysis
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... ) • Cutaneous Lesions ... Oral aphthae : SLE ... • Arthritis: SLE ... diagnosis #management #signs
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
response -> Subacute cutaneous ... inflammation on skin ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs ... #symptoms #complications
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... Presentation: Systemic Symptoms ... purpura: Strong sign ... of cutaneous leukocytoclastic ... • Progressive symptoms
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... dermatomyositis, Sjogren ... Seizures • Strokes Skin ... Induced Lupus: • Symptoms
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... salivary ducts Clinical ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... • Bilateral signs ... and/or symptoms ... or Sjogren's ... - Vasculitis-
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