29 results
Cutaneous and Systemic Findings in Dermatomyositis
Cutaneous Findings:
 - Heliotrope sign and edema
 - Nail-fold changes
 -
Systemic Findings in Dermatomyositis ... - Heliotrope sign ... or shawl sign ... #Dermatomyositis ... #Diagnosis #Rheumatology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Skin Conditions ... Seborrhea • Dermatomyositis ... Heliotrope • Dermatomyositis ... or plaques • Dermatomyositis ... differential #diagnosis #rheumatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
chest (in a V-sign ... shoulders (in a shawl sign ... Inverse Gottron’s sign ... ulcerations • Skin ... #rheumatology #
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
– symptoms and signs ... , Dry coarse skin ... , Deafness Signs ... Goitre), Dry skin ... #PhysicalExam #Endocrinology
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Dermatomyositis ... heliotrope rash, Shaw sign ... , holster sign, ... Myositis #diagnosis #rheumatology
Cushing Syndrome - Signs and Symptoms
Generalized: Weight gain, Slow healing of cuts, Increased risk of infections,
Cushing Syndrome - Signs ... Muscular: Weakness Skin ... Cushings #Syndrome #Signs ... Symptoms #diagnosis #endocrinology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
LcSSc) - distal skin ... thickening Signs ... changes): skin ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Hypothyroidism and Hyperthyroidism - Symptoms and Signs
Hypothyroidism:
 - General - From asymptomatic to myxedema coma, “Like
- Symptoms and Signs ... Menorrhagia - Skin ... • Skin is ... Hyperthyroid #Symptoms #Signs ... #Diagnosis #endocrinology
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Dermatomyositis ... processes occur in the skin ... flexors affected #Dermatomyositis ... Pathophysiology #Signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... tunnel, OSA, Incr skin ... #FeedbackLoop #endocrinology