16 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
ANCA (C-ANCA): GPA ... , MPA >>> GPA Stanford ... #differential # ... diagnosis #algorithm ... #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
the Skin - Differential ... Diagnosis Framework ... - GPA Cutaneous ... #rheumatology # ... differential #diagnosis
ANCA-Associated Vasculitis
There are many definitions, but most come down to the presence of granulomas (pathologically or
ANCA-Associated Vasculitis ... polyangiitis (GPA ... #differential # ... diagnosis #algorithm ... #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... polyangiitis (GPA ... Diagnosis: Vasculitis ... #dermatology #rash ... #diagnosis #rheumatology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... infection Malar rash ... Sarcoidosis • GPA ... #skin #rashes #differential ... #diagnosis #rheumatology
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA ... polyangiitis (MPA ... rarely PR3 Anti-GBM ... PANCA #MPO #PR3 #Diagnosis ... #Rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... - GPA - EGPA ... #Diagnosis #hematology ... #rheumatology #
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
- Differential ... Diagnosis Algorithm ... RA, Sjogren's, GPA ... deficiency Work ... #Differential #
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... Inflammatory Conditions: Rheumatologic ... , Vasculitides, ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
> PR3 60% • GPA ... mucositis - Rash ... • ANCA (Dx: GPA ... differential #diagnosis ... #rheumatology #