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ana antinuclear cytoplasmic hematology infections infectiousdiseases patterns agglutinin aids anemia autoimmune cold conditions disease extrarticular fungal hemolytic hiv management monoclonal
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Testing - Nuclear ... body-like: - Neurologic ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
HIV / AIDS - Differential ... Inferomedial temporal lobes ... of serum CrAg testing ... comparable to CSF testing ... #Infections #differential
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Testing Cytoplasmic ... body-like: • Neurologic ... #Patterns #differential ... #diagnosis #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
et diutinum Neurologic ... Scleromyxedema (CNS ... +GI+CVS+joints) ... #Monoclonal #Differential ... #Diagnosis #Oncology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
syndrome - SLE Neurologic ... Antiphospholipid-antibody ... ear, sparing the lobe ... #pain #differential ... #diagnosis #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome (CAS ... Positive Coombs testing ... - Mycoplasma, EBV ... younger pts) Differential ... hemolytic #anemia #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
affects the skin, neurologic ... vesicular eruption • Joints ... Palpable purpura, joint ... chorioretinitis, CNS ... #Diagnosis #Rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... muscle aches, joint ... Urinary antigen testing ... especially the CNS ... MC: CNS CSF: •
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... RP-ILD), dermato-rheumatologic ... Syndrome: Fever, joint ... • ANA < 20 % IBM ... #differential #
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