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hematology ana antinuclear cytoplasmic disease patterns workup agglutinin aids anemia arthritis autoimmune causes cns cold conditions disorders extrarticular hemolytic infections
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Testing - Nuclear ... body-like: - Neurologic ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... body-like: • Neurologic ... Rods/rings: • HCV ... #Patterns #differential ... #diagnosis #rheumatology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
/ AIDS - Differential ... Inferomedial temporal lobes ... effect/Edema • EBV ... of serum CrAg testing ... comparable to CSF testing
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... /HCV testing - ... (CVID, WAS), (neurologic ... When do you do a BM ... #Workup #hematology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Additional tests: HIV ... (to support a diagnosis ... laboratory #workup #diagnosis ... #testing #Rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
syndrome - SLE Neurologic ... Antiphospholipid-antibody ... ear, sparing the lobe ... #pain #differential ... #diagnosis #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Positive Coombs testing ... - Mycoplasma, EBV ... , HIV, rubella legionella ... younger pts) Differential ... hemolytic #anemia #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Zone Lymphoma (HCV ... et diutinum Neurologic ... Scleromyxedema (CNS+GI+CVS+joints ... #Monoclonal #Differential ... #Diagnosis #Oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... affects the skin, neurologic ... vesicular eruption • Joints ... Palpable purpura, joint ... #Diagnosis #Rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis - Differential ... RP-ILD), dermato-rheumatologic ... Syndrome: Fever, joint ... • ANA < 20 % IBM ... #differential #
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