62 results
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... Osmotic agents (mannitol ... urearetics) 3) Loop ... Adenosine #Nephron #Pathophysiology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Diuretics (e.g. mannitol ... ) 3) Loop Diuretics ... spironolactone) #Pathophysiology
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Causes of Hypernatremia ... Differential Diagnosis Algorithm ... water loss, Serum Sodium ... scheme) e.g., mannitol ... #Causes
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
overdose) - Sodium ... Furosemide and other loop ... Thiazides - Mannitol ... diagnosis #nephrology #Causes
Modified Hyponatremia Algorithm
Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants
Hypotonic Hyponatremia: 
 • ADH ON (UOsm > 100):
Modified Hyponatremia Algorithm ... Hyperglycemia, Mannitol ... #Hyponatremia #Algorithm ... #diagnosis #sodium
Nephron Remodeling as a Mechanism of Diuretic Resistance. When high doses of loop diuretics are used
high doses of loop ... thiazide-sensitive sodium ... the epithelial sodium ... #Pathophysiology
Hyponatremia - Differential Diagnosis Algorithm
Hypovolemic - Give volume
Hypervolemic (Edematous) - Look for and treat underlying cause
Differential Diagnosis Algorithm ... (Edematous) - Look ... treat underlying cause ... Differential #Diagnosis #Algorithm ... diagnosis #nephrology #sodium
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... ), Isosorbide, Mannitol ... as no effect on sodium ... nephrology #conversion #loop ... #thiazide #classes
Cyanide Toxicity 
Treatment:
1) Hydroxocobalamin + Cyanide = Cyanocobalamin (nontoxic) 
   or 
2) Amyl nitrite
Amyl nitrite - causes ... binds cyanide - Sodium ... Toxicity #Toxicology #Pathophysiology
Mechanisms of Loop Diuretic Action and Resistance. Panel A, loop diuretics circulate bound to protein. As
Mechanisms of Loop ... Panel A, loop diuretics ... for binding to sodium–potassium–chloride ... #Pathophysiology