29 results
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... disorders • Diagnosis ... and Treatment Algorithm ... #HES #Hematology ... #eosinophils #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
can present with rash ... , Shaw sign, holster ... anti-synthetase syndrome ... after 2 years of treatment ... #rheumatology
Clinical Manifestations of Serotonin Syndrome
 • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements)
 • Gastrointestinal: Diarrhea,
Clinical Manifestations ... of Serotonin Syndrome ... sounds, RUQ pain • Dermatologic ... Akathisia, Altered Mental ... #diagnosis
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
incidentally during medical ... glucocorticoid treatment ... organ-specific signs ... #Differential #diagnosis ... #hematology #eosinophilia
Nikolsky's Sign in Toxic Epidermal Necrolysis (TEN)

Nikolsky's sign is a clinical dermatological sign which is present
is a clinical dermatological ... differentiating between the diagnosis ... #TEN #Dermatology ... #PhysicalExam #Video ... #Clinical #SJS
Secondary Syphilis Rash
Secondary syphilis is the most contagious of all the stages of this disease, and
The signs and symptoms ... with or without treatment ... , but without treatment ... #Diagnosis #Clinical ... #Photo #Dermatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Clinical Presentation ... Petechial or purpuric rash ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
WBC >100k, + lab signs ... organ damage • Treatment ... Low calcium • Treatment ... #TLS #diagnosis ... #management #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... Maculopapular rash ... • Goodpasture syndrome ... #rash #diagnosis ... #rheumatology