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VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Somatic) Syndrome Clinical ... Syndrome: • Common Clinical ... Abnormalities: macrocytic anemia ... multiple myeloma, myelodysplastic ... multiple myeloma or myelodysplastic
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... Clinical Presentation ... • Hypocellular myelodysplastic
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... • Aplastic Anemia ... Megaloblastic Anemia ... Myelophthisic Anemia ... dyserythropoietic anemia
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Iron-deficiency anemia ... Sideroblastic anemia ... Megaloblastic anemia ... Liver diseases, Myelodysplastic ... , Pernicious anemia
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... cytopenias (usually anemia ... BrighamChiefs #Myelodysplastic
Dysplasia in Myelodysplastic Syndrome - Dysgranulopoiesis - Dyserythropoiesis - Dysmegakaryopoiesis #Dysplasias #MDS #Myelodysplastic
Dysplasia in Myelodysplastic ... Dysplasias #MDS #Myelodysplastic
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Framework for Anemia ... thalassemia • Anemia ... Normocytic" • Anemia ... Acute blood loss, Anemia ... Hypothyroidism, Myelodysplastic
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Poisoning • Anemia ... Marrow Failure • Anemia ... Hypothyroidism • Myelodysplasia ... #Anemia #MCV
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... • Myelodysplasia
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Pernicious Anemia ... • Pernicious Anemia ... Dysplastic • Myelodysplastic ... #Macrocytic #Anemia
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